Involvement of superoxide in the prolyl and lysyl hydroxylase reactions |
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Authors: | Raili Myllylä Lutz M. Schubotz Ulrich Weser Kari I. Kivirikko |
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Affiliation: | 1. Department of Medical Biochemistry, University of Oulu, Kajaanintie 52 A, SF-90220 Oulu 22, Finland;2. Anorganische Biochemie, Physiologisch-chemisches Institut der Universität Tübingen, Hoppe-Seyler-Str. 1, D-7400 Tübingen, West-Germany |
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Abstract: | Four superoxide dismutase active copper chelates, Cu(acetylsalicylate)2, Cu(salicylate)2, Cu(lysine)2 and Cu(tyrosine)2, proved to be inhibitors of prolyl and lysyl hydroxylase. The kinetics of the inhibition are consistent with the proposal that these compounds dismutated at the active site of the enzymes. The data strongly suggest that is the active form of O2 in the prolyl and lysyl hydroxylase reactions. |
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