Na+-dependent,electroneutral l-ascorbate transport across brush border membrane vesicles from guinea pig small intestine |
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Authors: | Luca Siliprandi Paolo Vanni Markus Kessler Giorgio Semenza |
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Affiliation: | Laboratorium für Biochemie der E.T.H., Universitätstrasse 16, CH-8092 Zürich Switzerland |
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Abstract: | In brush border vesicles from guinea pig small intestine l-ascorbate transport is Na+-dependent and electroneutral (in the presence of Na+, as shown by its lack of response to either positive or negative Δψ across the membrane).l-Ascorbate transporter has the kinetic characteristics of a mobile carrier (Km for l-ascorbate, 0.3 mM). d-Isoascorbate (erythorbate) seems to be another, but poorer, substrate of the same transporter.l-Ascorbate transport is subjected to heterologous inhibition by d-glucose. |
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Keywords: | Heterologous inhibition Electroneutral transport (Brush border vesicle, Guinea pig) Hepes |
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