Studies on antiviral glycosides. II. Mode of action for virucidal effects on Sendai virus |
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Authors: | Kenji Sugita,Hitoshi Arita,Kosaburo Sato,Jun ichi Kawanami |
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Affiliation: | Shionogi Research Laboratory, Shionogi & Co., Ltd., Fukushima-ku, Osaka, 553 Japan |
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Abstract: | Treatment of Sendai virus with , followed by freezing and thawing resulted in a loss of hemolytic and cell fusion activities as well as infectivity without affecting hemagglutinating and neuraminidase activities. The anti-hemolytic activity of this compound was reversed by the addition of phosphatidyl choline to the virus samples. was successfully used for photoaffinity labeling of a specific virion site, and we confirmed the affected site of the glucoside to be the lipid components in the viral envelopes. |
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Keywords: | Phenyl glycoside Virucidal agent Cell fusion Hemolytic activity Photoaffinity label (Sendai virus) |
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