Anti-inflammatory cyclohexenyl chalcone derivatives in Boesenbergia pandurata. |
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| Authors: | Patoomratana Tuchinda Vichai Reutrakul Per Claeson Ubonwan Pongprayoon Tuanta Sematong Thawatchai Santisuk Walter C Taylor |
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| Affiliation: | Department of Chemistry, Faculty of Science, Mahidol University, Rama VI Road, Bangkok 10400, Thailand. scptc@mahidol.ac.th |
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| Abstract: | The cyclohexenyl chalcone derivative [(-)-hydroxypanduratin A], together with the previously known panduratin A, sakuranetin, pinostrobin, pinocembrin, and dihydro-5,6-dehydrokawain were isolated from the chloroform extract of the red rhizome variety of Boesenbergia pandurata (Robx.) Schltr. [currently known as Boesenbergia rotunda (L.) Mansf., Kulturpfl.]. Their structures were assigned on the basis of their spectroscopic data. (-)-Hydroxypanduratin A and (-)-panduratin A showed significant topical anti-inflammatory activity in the assay of TPA-induced ear edema in rats. |
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| Keywords: | Boesenbergia pandurata Boesenbergia rotunda Zingiberaceae Red rhizome variety Cyclohexenyl chalcone derivatives Flavanones 2-Pyrone Anti-inflammatory activity |
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