Contribution of the Endogenous Opioid System to Regulation of Heart Resistance to the Arrhythmogenic Effect of Short-term Ischemia and Reperfusion |
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| Authors: | L N Maslov A Yu Lishmanov E V Budankova D L Stakheev N V Solenkova E I Barzakh P R Oeltgen G J Gross W S Chang |
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| Institution: | (1) Tomsk State Pedagogical University, Tomsk, 634041, Russia;(2) Institute of Cardiology, Tomsk Research Center, Siberian Division, Russian Academy of Medical Sciences, ul. Kievskaya 111, Tomsk, 634050, Russia;(3) College of Medicine, University of Kentucky, Lexington, Kentucky 40506, USA;(4) Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA;(5) Sanofi Synthelabo Research, Malvern, Pennsylvania 19355, USA |
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| Abstract: | Preliminary selective blockade of µ, δ1, δ2, κ1, and κ2 opioid receptors proved to have no effect on the incidence of ventricular arrhythmias during a 10-min coronary occlusion and subsequent reperfusion in ket-amine-anesthetized rats. We propose that the endogenous opioid system has no considerable role in regulation of heart resistance to the arrhythmogenic effect of short-term local ischemia and subsequent reperfusion.__________Translated from Izvestiya Akademii Nauk, Seriya Biologicheskaya, No. 4, 2005, pp. 453–459.Original Russian Text Copyright © 2005 by Maslov, Lishmanov, Budankova, Stakheev, Solenkova, Barzakh, Oeltgen, Gross, Chang. |
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