The genomic structure of C14orf1 is conserved across eukarya |
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| Authors: | Chris Ottolenghi Iraj Daizadeh Albert Ju Sophia Kossida Georges Renault Michel Jacquet Arlette Fellous Walter Gilbert Reiner Veitia |
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| Institution: | (1) Unité d'Immunogénétique Humaine, Institut Pasteur, 25 rue du Dr. Roux, 75724, Paris, France, FR;(2) Dipartimentro di Morfologia ed Embriologia, Universita di Ferrara, Italy, IT;(3) Department of Molecular and Cellular Biology, Harvard University, Boston, Massachusetts, USA, US;(4) Laboratoire d'Information Génétique et Développement, Université Paris Sud, France, FR;(5) Laboratoire de Pharmacologie Experimentale et Clinique, Institut de Génétique Moléculaire, Paris, France, FR;(6) Departamento de Bioquimica, Universidad de la Habana, Cuba, CU |
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| Abstract: | We have recently cloned the gene C14orf1, which is strongly expressed in normal testis and in several cancer cell lines and
tumors. This gene maps to 14q24.3 and is interrupted by four introns. Two of them are also represented in the open reading
frame of Schizosaccharomyces pombe in the same phase. In Arabidopsis taliana only the first of the two introns was found, in the same phase as the corresponding ones in S. pombe and human. Disruption of the ortholog in Saccharomyces cerevisiae (Yer044c) led to a severe growth defect, and C14orf1 failed to complement mutant yeast when put under the control of the
natural Yer044c promoter. Further studies are needed to understand the causes underlying the high degree of conservation of the C14orf1 genomic
structure.
Received: 7 February 2000 / Accepted: 14 April 2000 |
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