Tuberoinfundibular Peptide of 39 Residues- Immunoreactive Fibers in the Zona Incerta and the Supraoptic Decussations Terminate in the Neuroendocrine Hypothalamus |
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Authors: | Palkovits M Usdin T B Makara G B Dobolyi A |
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Institution: | 1.Neuromorphological and Neuroendocrine Research Laboratory, Department of Anatomy, Histology and Embryology, Semmelweis University and The Hungarian Academy of Sciences, Tüzoltó-utca 58, 1094, Budapest, Hungary ;2.Section on Fundamental Neuroscience, National Institute of Mental Health, NIH, Bethesda, MD, USA ;3.Institute of Experimental Medicine, Hungarian Academy of Sciences, 1450, Budapest, Hungary ; |
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Abstract: | Tuberoinfundibular peptide of 39 residues (TIP39) is expressed by neurons in the subparafascicular area, the posterior intralaminar
complex of the thalamus and the pontine medial paralemniscal nucleus. TIP39-positive fibers from these areas do not form individual
bundles or fascicles, they join other pathways to reach their innervated brain areas. Fibers arise from TIP39 perikarya located
in the subparafascicular area and the posterior intralaminar complex of the thalamus could be followed to the hypothalamus.
After uni- and bilateral posterolateral surgical deafferentations of the hypothalamus, accumulation of TIP39 immunoreactivity
was observed in the fibers caudal to the knife cut, while it disappeared completely rostral to the transection. In serial
sections of the forebrain, we could follow TIP39-ir fibers coursing within the zona incerta and the supraoptic decussations.
TIP39-positive fibers that join the incerto-hypothalamic pathway reach the medio-dorsal part of the hypothalamus and form
moderate to high density networks in the dorsomedial and paraventricular nuclei. The other set of TIP39-positive axons from
the subthalamic area join the fibers of the supraoptic decussations and run in an antero-medial direction through the most
ventral portion of the hypothalamus up to the retrochiasmatic area, where they crossover. A certain portion of these TIP39-positive
fibers terminates in the territories of the arcuate and the medial preoptic nuclei, as well as in the retrochiasmatic area. |
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