Key adhesin gene in community-acquired methicillin-resistant Staphylococcus aureus |
| |
Authors: | Otsuka Taketo Saito Kohei Dohmae Soshi Takano Tomomi Higuchi Wataru Takizawa Yoko Okubo Takeshi Iwakura Nobuhiro Yamamoto Tatsuo |
| |
Institution: | Division of Bacteriology, Department of Infectious Disease Control and International Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan. |
| |
Abstract: | Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) possessing the Panton-Valentine leukocidin (PVL) gene (luk(PV)) is associated with skin and soft tissue infections, osteomyelitis, and necrotizing pneumonia. There are geographically two types of CA-MRSA: one (sequence type ST30) that is worldwide (pandemic) and the other (sequence types, e.g., ST1, ST8 or ST80) that is continent-specific. The pandemic type, but not continent-specific type, possessed the bone sialoprotein-adhesin gene (bbp), which was associated with osteomyelitis. No recent hospital-acquired MRSA had the bbp gene, while past PVL-positive nosocomial outbreak-derived strains did possess it. The collagen-adhesin gene (cna) was associated with pandemic CA-MRSA, though with positive cases even in continent-specific CA-MRSA and PVL-negative Japanese region-specific CA-MRSA. Thus, the pandemic type is characterized by the combination of luk(PV) and bbp (and cna) genes. A specific real-time PCR assay for the bbp gene was developed, and dual assay for bbp and luk(PV) in one test tube became possible. |
| |
Keywords: | Bone sialoprotein-adhesin gene Collagen-adhesin gene Panton-Valentine leukocidin gene Methicillin-resistant Staphylococcus aureus Community-acquired MRSA Pandemic clone Real-time PCR bbp cna lukPV |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|