Spatio-temporal expression of MMP-2, MMP-9 and tissue kallikrein in uteroplacental units of the pregnant guinea-pig (Cavia porcellus) |
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| Authors: | Jenny Corthorn Sergio Rey Cecilia Chacón and Gloria Valdés |
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| Institution: | (1) Departamento de Nefrolog?a Escuela de Medicina, Pontificia Universidad Cat?lica de Chile, Marcoleta 391, 8330024 Santiago, Chile;(2) Centro de Investigaciones M?dicas, Escuela de Medicina, Pontificia Universidad Cat?lica de Chile, Santiago, Chile |
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| Abstract: | Background In humans trophoblast invasion and vascular remodeling are critical to determine the fate of pregnancy. Since guinea-pigs
share with women an extensive migration of the trophoblasts through the decidua and uterine arteries, and a haemomonochorial
placenta, this species was used to evaluate the spatio-temporal expression of three enzymes that have been associated to trophoblast
invasion, MMP-2, MMP-9 and tissue kallikrein (K1). |
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