Effects of lipid physicochemical characteristics on interrelations between lipid composition and the mouse liver index

Interrelations between the liver index (the relative mass) and various parameters of the liver lipid composition in 9 groups of intact female SHK mice sacrificed at different Seasons and years groups were studied depending on physicochemical characteristics of their lipids. There were revealed correlations between the liver index and the following parameters of the lipid composition: relative content of cardiolipin, lysoforms of the phospholipid/phosphatidylcholine ratio in liver phospholipids, and the [serine]/[phospholipids] molar ratio. The direction of these correlations has been established to depend on the lipid physicochemical characteristics. In all cases, there is observed a direct correlation if lipids have prooxidant properties and antiperoxide activity and an inverse correlation if lipids are characterized by antioxidant and antiperoxide activities.