Cancer-associated antigens and antigen arrays in serological diagnostics of malignant tumors |
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Authors: | P. V. Belousov D. V. Kuprash A. Yu. Sazykin S. V. Khlgatian D. N. Penkov Yu. V. Shebzukhov S. A. Nedospasov |
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Affiliation: | Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991, Russia. belous_p@rambler.ru. |
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Abstract: | The appearance of antibodies to cancer-associated antigens in biological fluids (particularly, in blood sera) of cancer patients is now a well-established fact, and their detection by immunochemical methods is a promising approach to diagnostics of malignant neoplasms. In this review, we consider some immunobiological aspects of the most extensively studied cancer-associated B-cell antigens, various applications of autoantibodies as cancer biomarkers, and prospects for the use of antigen arrays for improving diagnostic sensitivity. |
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Keywords: | cancer-associated antigens autoantibodies serological diagnostics of cancer |
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