Activities of myelin bound cytidine 5′-diphosphate-choline 1, 2 diacyl-glycerol choline phosphotransferase and uridine 5′-diphosphate-galactose-ceramide galactosyltransferase under restricted food intake |
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Authors: | S Padmini P Srinivasarao |
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Institution: | (1) National Institute of Nutrition, 500 007 Hyderabad, India |
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Abstract: | Activities of cytidine 5′-diphosphate-choline glycerol choline phosphotransferase and uridine 5′-diphosphate galactose-ceramide
galactosyltransferase were determined in isolated myelin in different brain regions of control, and rats with restricted food
intake. Kinetic experiments indicated an increase inK
m value of phosphocholinetransferase in brain stem of undernourished rats, without significant change in the specific activity
of this enzyme. Stimulation of this myelin bound enzyme activity was also evident in the animals when myelin was treated with
the detergent: Tween CF. 54. Though specific activities of galactosyl transferase in myelin of undernourished rats were significantly
diminished, theK
m of this enzyme was unaltered. These studies point to an adverse effect of early nutritional stress on the activities of enzymes
bound to myelin membrane which has hitherto been considered metabolically inert. |
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Keywords: | Myelin UDP-galactose-ceramide galactosyltransferase CDP-choline nutritional stress |
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