Lateral signaling mediated by axon contact and calcium entry regulates asymmetric odorant receptor expression in C. elegans |
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Authors: | Troemel E R Sagasti A Bargmann C I |
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Institution: | Howard Hughes Medical Institute, Department of Anatomy, The University of California, San Francisco 94143-0452, USA. |
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Abstract: | C. elegans detects several odorants with the bilaterally symmetric pair of AWC olfactory neurons. A stochastic, coordinated decision ensures that the candidate odorant receptor gene str-2 is expressed in only one AWC neuron in each animal--either the left or the right neuron, but never both. An interaction between the two AWC neurons generates asymmetric str-2 expression in a process that requires normal axon guidance and probably AWC axon contact. This interaction induces str-2 expression by reducing calcium signaling through a voltage-dependent Ca2+ channel and the CaM kinase II UNC-43. CaMKII activity acts as a switch in the initial decision to express str-2; thus, calcium signals can define distinct cell types during neuronal development. A cGMP signaling pathway that is used in olfaction maintains str-2 expression after the initial decision has been made. |
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