Sodium-activated potassium current in mouse diaphragm |
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Authors: | L Re V Moretti L Rossini P Giusti |
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Affiliation: | Department of Pharmacology--I.M.O., University Medical School, Ancona, Italy. |
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Abstract: | The mouse diaphragm muscle fiber was studied using the loose patch clamp technique. The voltage gated sodium currents were evoked by step pulses from a holding potential of about −70 mV. Following the activation of the sodium current, a very large and fast outward current was evoked. The sensitivity of this current to 4-aminopyridine and tetraethylammonium indicates the potassium ion as the possible carrier for the channel. Furthermore, the sensitivity to tetrodotoxin and extracellular sodium demonstrated the sodium dependence of this current. |
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Keywords: | Potassium channel Loose patch clamp Mouse diaphragm |
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