Planning for remodelling: nuclear architecture,chromatin and chromosomes |
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Authors: | Heslop-Harrison J S |
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Institution: | Department of Biology, University of Leicester, Leicester LE1 7RH, UK. phh4@le.ac.uk |
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Abstract: | DNA sequences occupy three-dimensional positions and their architecture is related to gene expression, gene-protein interactions and epigenetic processes. The recent analysis of chromosome 4 in Arabidopsis interphase nuclei reveals that gene-rich, undermethylated DNA is composed of active loops of 200 to 2000 kb associated with acetylated histones, providing a well-defined model system to study chromatin in its nuclear context. |
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