An image-based method to measure joint deformity in inflammatory arthritis: development and pilot study |
| |
| Authors: | Travis F. Henchie Ellen M. Gravallese Todd L. Bredbenner |
| |
| Affiliation: | 1. Department of Biomedical Engineering, Worcester Polytechnic Institute, Worcester, Massachusetts, USA;2. Division of Rheumatology, University of Massachusetts Memorial Medical Center and University of Massachusetts Medical School, Worcester, Massachusetts, USA;3. Department of Mechanical and Aerospace Engineering, University of Colorado Colorado Springs, Colorado Springs, Colorado, USA |
| |
| Abstract: | Quantifying joint deformity in people with rheumatoid (RA) and psoriatic arthritis (PsA) remains challenging. Here, we demonstrate a new method to measure bone erosions and abnormal periosteal growths, based on the difference between a predicted healthy and actual diseased joint surface. We optimized the method by creating and measuring artificial bone erosions and growths. Then we measured 46 healthy and diseased patient surfaces. We found average sensitivity errors of ≤0.27?mm when measuring artificial erosions and growths. Patients had significantly more bone erosion than healthy subjects. Surface based outcomes are a novel way to interpret and quantify bone changes in PsA and RA. |
| |
| Keywords: | Coherent point drift HRpQCT CT imaging inflammatory arthritis MCP |
|
|
