Damage to the creatine phosphokinase of rat brain synaptosomes during molecular oxygen activation

It was shown that activation of molecular oxygen by Fe2+ ascorbate causes damage to creatine phosphokinase of rat brain synaptosomes. The creatine phosphokinase inactivation did not correlate with activation of lipid peroxidation in synaptosomes. The enzyme damage was the result of direct interaction with active oxygen species.