Using of electrochemical methods for studying of metallothionein content in the human blood serum of a patient poisoned by lead and treated by platinum |
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| Authors: | Petrlová Jitka Blastík Ondrej Průsa Richard Kukacka Jirí Potĕsil David Mikelová Radka Adam Vojtĕch Zehnálek Josef Kizek René |
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| Institution: | Department of Chemistry and Biochemistry, Faculty of Agronomy, Mendel University of Agriculture and Forestry, Zemedelská 1, Brno, CZ-613 00, Czech Republic. kizek@sci.muni.cz. |
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| Abstract: | Metallothioneins belong to the group of intracellular, high molecular and cysteine-rich proteins whose content increase with increasing concentration of a heavy metal. Here we applied the adsorptive transfer stripping differential pulse voltammetry Brdicka reaction for the determination of metallothionein in human blood serum of patient poisoned by lead and/or treated by platinum. The increased metallothionein concentrations in both cases were observed. |
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