Role of WNT signaling in normal and malignant hematopoiesis |
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| Authors: | Khan N I Bendall L J |
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| Affiliation: | Westmead Institute for Cancer Research, Westmead Millennium Institute, University of Sydney, Westmead, Australia. |
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| Abstract: | The WNT pathway is a powerful signaling pathway that plays a crucial role in cell fate determination, survival, proliferation and movement in variety of tissues. Abnormalities in the WNT signaling pathway have been implicated in a number of diseases, most notably cancer. Recent exciting evidence suggests that WNT signaling also plays an important role in hematopoietic stem cell self-renewal and progenitor development. In this review we discuss current state of knowledge on WNT signaling in hematopoiesis and extend our focus on aberrant WNT signaling in hematological malignancies. |
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