Effectivity of new acetylcholinesterase reactivators in treatment of cyclosarin poisoning in mice and rats |
| |
Authors: | Bartosová Lucie Kuca Kamil Kunesová Gabriela |
| |
Affiliation: | Department of Toxicology, Faculty of Military Health Sciences, Hradec Králové, Czech Republic. bartosova@pmfhk.cz |
| |
Abstract: | The present study was performed to assess and compare a therapeutic efficacy of obidoxime, HI-6, BI-6 and HS-6 administered in equimolar doses and combined with atropine in cyclosarin-poisoned mice and rats. It was demonstrated that all the therapeutic regimens tested, were able to decrease the cyclosarin-induced toxicity significantly - at least 1.5 times. Higher therapeutic ratios, almost three times, were achieved in rats in comparison with mice. The highest therapeutic ratio was achieved for therapeutic regimen consisting of HI-6 and atropine in both mice and rats. Obidoxime was the least effective oxime in the treatment of cyclosarin intoxication. The BI-6 oxime was significantly more efficacious than obidoxime (in both mice and rats) and HS-6 (in rats) but its effectiveness did not reach the efficacy of HI-6. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|