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Chromosomal localization of the human and mouse histidine decarboxylase genes by in situ hybridization. Exclusion of the HDC gene from the Prader-Willi syndrome region |
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| Authors: | Perrine Malzac Marie-Geneviève Mattei Jean Thibault Gilles Bruneau |
| Institution: | (1) Physiopathologie Chromosomique, Hôpital d'Enfants de la Timone, Unité de Recherche No 242, F-13 385 Marseille Cedex 5, France;(2) Laboratoire de Biochimie Cellulaire, Collège de France, F-75231 Paris Cedex 05, France;(3) Laboratoire de Neuroendocrinologie Sexuelle, INRA, F-37380 Nouzilly, France |
| Abstract: | Using a rat histidine decarboxylase (HDC) cDNA probe, we have mapped the HDC gene by in situ hybridization to the ql5–q2l region of human chromosom e15 and to the E5-G region of murine chromosome 2. These localizations strengthen a syntenic group conserved between human chromosome 15 and mouse chromosome 2. The localization of the HDC gene on the human chromosome 15 map shows that it is not included within the Prader-Willi Syndrome region (PWCR). |
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