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TAK1-mediated transcriptional activation of CD28-responsive element and AP-1-binding site within the IL-2 promoter in Jurkat T cells
Authors:Sakurai Hiroaki  Singhirunnusorn Pattama  Shimotabira Emi  Chino Atsushi  Suzuki Shunsuke  Koizumi Keiichi  Saiki Ikuo
Affiliation:Division of Pathogenic Biochemistry, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Toyama 930-0194, Japan. hsakurai@ms.toyama-mpu.ac.jp
Abstract:
Keywords:TAK1, transforming growth factor-β-activated kinase 1   TAB1, TAK1-binding protein 1   IL-2, interleukin-2   TCR, T cell receptor   MAPK, mitogen-activated protein kinase   JNK, c-Jun NH2-terminal kinase   ERK, extracellular signal-related kinase   MAP3K, MAPK kinase kinase   AP-1, activator protein-1   NF-κB, nuclear factor-κB   IKK, IκB kinase   RE/AP, CD28-response element/AP-1-binding site   TPA, 12-O-tetradecanoylphorbol-13-acetate
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