Preparation,structural characterization and <Emphasis Type="Italic">in vitro</Emphasis> antitumor activity of <Emphasis Type="Italic">kappa</Emphasis>-carrageenan oligosaccharide fraction from <Emphasis Type="Italic">Kappaphycus striatum</Emphasis> |
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Authors: | Huamao?Yuan Email author" target="_blank">Jinming?SongEmail author |
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Institution: | (1) Chinese Academy of Sciences, Institute of Oceanology, Qingdao, 266071, People’s Republic of China;(2) Graduate School of the Chinese Academy of Sciences, Beijing, 100039, People’s Republic of China |
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Abstract: | Oligosaccharides were prepared through mild hydrochloric acid hydrolysis of kappa-carrageenan from Kappaphycus striatum to compare the antitumor activity with carrageenan polysaccharides. Oligosaccharide fractions were isolated by gel permeation chromatography and the structure of fraction 1 (F1) was studied by using negative-ion electrospray ionization-mass spectrometry (ESI-MS), and 1H and 13C-NMR spectrometry. The in vitro antitumor effects in three human neoplastic cell lines (KB, BGC, and Hela) of polysaccharides and F1 were investigated. The bioassay results showed that F1 exhibited relatively higher antitumor activity against the three cancer cells than polysaccharides. |
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Keywords: | kappa-carrageenan Kappaphycus striatum oligosaccharides antitumor |
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