Seasonal variation in the apparent number of binding sites for 3H-opioid agonists and antagonists |
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Authors: | E E Codd W L Byrne |
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Affiliation: | Department of Biochemistry, University of Tennessee Center for the Health Sciences, Memphis, TN 38163, USA |
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Abstract: | Throughout the year, a radioreceptor assay was used to investigate the number of binding sites for several opioid ligands in C57BL/6J mouse brain homogenates. The mean number of sites observed for 3H-morphine and 3H-dihydromorphine was about one third less than the mean for 3H-D-ala2-met5-enkephalinamide, 3H-naloxone or 3H-naltrexone. Some seasonal variation was observed in all the opioids studied; the seasonal fluctuation observed in the apparent number of naloxone binding sites was the greatest. These seasonal alterations may play a role in the annual pattern of several physiological processes in which endorphin systems are directly or indirectly involved. |
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