| 脑内芳香化酶表达的定位、调控及意义 |
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| 引用本文： | Zhang JQ,Cai WQ. 脑内芳香化酶表达的定位、调控及意义[J]. 生理科学进展, 2001, 32(2): 107-111 |
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| 作者姓名： | Zhang JQ Cai WQ |
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| 作者单位： | 第三军医大学组织学与胚胎学教研室, |
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| 基金项目： | 国家自然科学基金资助课题(3987024) |
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| 摘 要： | 芳香化酶催化雄激素转化为雌激素,在脑内其表达主要见于下丘脑与边缘系统的神经元内,星形胶质细胞可能也表达芳香化酶。芳香化酶基因表达是由多个组织特异性的启动子驱动的。脑内雌激素的有效浓度取决于脑局部芳香化酶的表达水平,由此产生的雌激素能调节突触发生和树突棘密度、神经营养因子和／或其受体的表达,保护脑细胞免受包括β－淀粉样蛋白在内的多种神经毒素的影响,并可显著改善老年性痴呆（AD）导致的学习和记忆下降及认知缺陷。
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| 关 键 词： | 脑 芳香化酶 雌激素 基因表达 调控 定位 |
A review of brain aromatase |
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| Zhang J Q,Cai W Q. A review of brain aromatase[J]. Progress in Physiological Sciences, 2001, 32(2): 107-111 |
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| Authors: | Zhang J Q Cai W Q |
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| Affiliation: | Department of Histology and Embryology, Third Military Medical University, Chongqing 400038. |
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| Abstract: | Aromatase catalyzes the conversion of androgen to estrogen. This enzyme has been primarily localized in the neurons of specific areas of limbic system and hypothalamus of the brain. Astrocytes may also express this enzyme. Studies show that the gene expression of aromatase is driven by multiple tissue specific exons, and the effective concentration of brain estrogen depends on the expression of brain aromatase. The locally produced estrogen plays an important role in the regulation of synaptogenesis, density of dendritic spine and the expression of neurotrophic factors and/or their receptors. Estrogen can also protect brain cells from the damages of neurotoxins and can greatly improve the deficits of learning and memory resulted from neurodegenerative disorders such as Alzheimer's diseases. |
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| Keywords: | Brain Aromatase Estrogen |
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