The relationship between nerves and smooth muscle cells in the rat iris

Summary The sphincter muscle in the rat iris forms irregular strands in the stroma. Bundles of unmyelinated axons run among the muscle cells. After sympathetic denervation some axons degenerate. This should indicate that sympathetic and parasympathetic nerves are present in the same nerve net. The parasympathetic axons possess varicosities, that is, enlargements containing mitochondria and synaptic vesicles. These varicosities show a similar structural relationship to the muscle cells as do the varicosities of sympathetic nerves. No obvious ultrastructural difference is observed between the sympathetic and parasympathetic varicosities.This study has been supported by research grants (U267 and Y247) from the Swedish Medical Research Council and by a Public Health Service Research Grant (NB05236-01) from the National Institute of Neurological Diseases and Blindness.