| E2F-1基因在肺癌中的表达及意义 |
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| 引用本文： | 杨志鸿,阮永华,金克炜,高倩,张林.E2F-1基因在肺癌中的表达及意义[J].生物磁学,2011(24):4828-4830. |
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| 作者姓名： | 杨志鸿 阮永华 金克炜 高倩 张林 |
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| 作者单位： | [1]昆明医学院病理教研室,云南昆明650031 [2]昆明医学院第一附属医院病理科,云南昆明650031 |
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| 摘 要： | 目的：探讨E2F-1基因在肺癌中的表达及意义。方法：采用免疫组化S-P法,检测60例肺癌及20例正常肺组织中E2F-1基因蛋白的表达情况。结果：E2F-1在肺癌组织中的阳性率为91.7%,显著高于正常肺组织的10%,两组间差异有显著性（P〈0.05）;E2F-1与肺癌患者的性别、年龄、组织学类型、分化程度及淋巴结转移等无相关性（P〉0.05）。结论：E2F-1的异常高表达在肺癌的发生发展中起重要作用,可作为肺癌基因诊断和治疗的靶点。
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| 关 键 词： | 肺癌 E2F-1基因 |
The Expression of E2F-1 Gene in Lung Cancer |
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| YANG Zhi-hong,RUAN Yong-hua,JIN Ke-wei,GAO Qian,ZHANG Lin.The Expression of E2F-1 Gene in Lung Cancer[J].Biomagnetism,2011(24):4828-4830. |
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| Authors: | YANG Zhi-hong RUAN Yong-hua JIN Ke-wei GAO Qian ZHANG Lin |
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| Institution: | 1 Department of pathology,Kunming medical school,Kunming,Yunnan,650031,China;2 Department of pathology,the first affiliated hospital of Kunming medical school,Kunming,Yunnan,650031,China) |
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| Abstract: | Objective： To investigate the expression of E2F-1 in lung cancer.Methods： The expression of E2F-1 was detected at their protein level by Immunohistochemistry S-P method in 60 specimens of lung cancer and 20 specimens of normal lung tissue.Results： The positive expression of E2F-1 was 91.7%,which was significantly higher than 10% in normal lung tissues,and there was a signifi-cant difference between the two（P0.05）;there was no relation between the expression of E2F-1 and the characteristics of lung cancer,i.e sex,age,tumor pathological type,differentiation,lymph node metastasis（P0.05）.Conclusion： The expression of E2F-1 may play an important role in the occurrence of Lung cancer,and can be used to gene diagnosis. |
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| Keywords: | Lung cancer E2F-1 gene |
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