| 2型糖尿病家系患者LEPR基因Gln223Arg多态性的研究 |
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| 引用本文： | 孙宏,苗长青,赵晓雯,张慧娟,李艺萍,梁立波,曹佳,王月影,孙亮,杨泽. 2型糖尿病家系患者LEPR基因Gln223Arg多态性的研究[J]. 生物磁学, 2011, 0(24): 4852-4856 |
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| 作者姓名： | 孙宏 苗长青 赵晓雯 张慧娟 李艺萍 梁立波 曹佳 王月影 孙亮 杨泽 |
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| 作者单位： | [1]哈尔滨医科大学公共卫生学院,黑龙江哈尔滨150086 [2]哈尔滨医科大学附属第一医院内分泌科,黑龙江哈尔滨150001 [3]卫生部北京医院老年医学研究所,北京100730 |
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| 基金项目： | 黑龙江省教育厅科学技术研究项目（11521145） |
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| 摘 要： | 目的：研究黑龙江地区汉族人2型糖尿病家系的LEPR基因Gln223Arg多态性,探讨其与2型糖尿病发病的关系。方法：应用聚合酶链式反应-限制性内切酶长度多态性（PCR-RFLP）技术,对来自于黑龙江地区120个2型糖尿病家系中的210例2型糖尿病患者及319例正常对照的LEPR基因Gln223Arg（668 A→G）位点进行基因分型。结果：LEPR基因Gln223Arg三种基因型在病例组和对照组间整体分布有统计学意义（P=0.034,df=2）;除AG基因型（x2=4.550,P〈0.01）外,其余各基因型及等位基因在病例组和对照组间分布未见显著性差异（P〉0.05）。结论：LEPR基因Gln223Arg多态性与黑龙江地区汉族人2型糖尿病有关,LEPR基因可能为中国人2型糖尿病发病的相关易感基因。
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| 关 键 词： | 2型糖尿病 LEPR基因 单核苷酸多态性 |
LEPR Gene Gln223Arg Polymorphism in Chinese Families with Type 2 Diabetes |
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| SUN Hong,MIAO Chang-qing,ZHAO Xiao-wen,ZHANG Hui-juan,LI Yi-ping,LIANG Li-bo,CAO Jia,WANG Yue-ying,SUN Liang,YANG Ze. LEPR Gene Gln223Arg Polymorphism in Chinese Families with Type 2 Diabetes[J]. Biomagnetism, 2011, 0(24): 4852-4856 |
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| Authors: | SUN Hong MIAO Chang-qing ZHAO Xiao-wen ZHANG Hui-juan LI Yi-ping LIANG Li-bo CAO Jia WANG Yue-ying SUN Liang YANG Ze |
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| Affiliation: | 1 Department of Health Management,Harbin Medical University,Harbin 150086,China;2 Department of Endocrinology,The First Hospital of Harbin Medical University,Harbin 150001,China;3 Institute of Geriatrics,Beijing Hospital,Ministry of Health,Beijing 100730,China) |
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| Abstract: | Objective： To detect LEPR gene Gln223Arg polymorphism in Heilongjiang Han families with type 2 diabetes and to investigate their relationship with type 2 diabetes.Methods： PCR-RFLP method was used to test the polymorphisms of LEPR Gln223Arg（668 A→G） in 210 individuals from 120 type 2 diabetes families and 319 normal control subjects in Heilongjiang area.Results： The overall distribution of the three genotypes of LEPR gene Gln223Arg between cases and controls was significantly different（P=0.034,df=2）.Except AG genotype（x2=4.550,P0.01）,the distribution of the rest of the genotypes and alleles between cases and controls had no significant difference（P0.05）.Conclusion： LEPR gene Gln223Arg polymorphism is related to type 2 diabetes in Heilongjiang Han na-tionality.LEPR gene may be a related gene of type 2 diabetes in Chinese. |
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| Keywords: | Type 2 diabetes LEPR gene Single nucleotide polymorphism |
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