胃癌组织中Tenascin、MVD、Ki-67的表达及其临床意义

目的：探讨胃癌组织中Tenascin蛋白、微血管密度（microvascular density,MVD）、Ki-67的表达及其与临床病理特征的关系。方法：采用免疫组化Elivision法检测70例胃癌组织和20例癌旁正常组织中Tenascin、CD34和Ki-67的表达。结果：①正常胃黏膜上皮Tenascin阴性，胃癌中的Tenascin主要表达于肿瘤相关纤维母细胞的胞质中，且与胃癌的Lauren分型、分化程度、临床分期、淋巴结转移显著相关（P〈0．05）；②胃癌中MVD和Ki-67-LI（标记指数）均高于正常胃黏膜（P〈0．001），且均与胃癌的临床分期、浸润深度、淋巴结转移显著相关（P〈0．05）；结论：胃癌组织中Tenascin可抑制胃癌的演进，MVD及Ki-67可作为胃癌患者预后的预测指标，联合检测胃癌组织Tenascin、MVD、Ki-67的表达情况，对于进一步了解胃癌的生物学行为和判断预后具有一定的临床价值与意义。

Expression of Tenascin, MVD, Ki-67 in Gastric Adenocarcinoma and Their Clinical Significance

Objective： To investgate the expression of Tenascin, microvascular density （MVD）, Ki-67 in gastric carcinoma and their relationship with elinienpathologie features. Methods： The expression of Tenascin, CD34 and Ki-67 in 70 eases of gastric carcinoma and 20 eases of normal gastric tissue was detected by immunohistoehemistry. Results： （1） Tenasein was mainly expressed in tumor assoeiated fibroblasts and the level of its expression was associated with Lauren classification, differentiation degree, TNM tumour stage and lymph node metastases （1）〈0.05）; （2） The expression of MVD and Ki-67-LI was significantly higher in gastric cancer than in normal gastric tissue （P〈0.001）, both of them were respectively correlated with the TNM turnout stage, the depth oftumour invasion and lymph node metastases （P〈0.05）. Conclusions： Tenasein may inhibit the development of gastric cancer. Quantitation of MVD and Ki-67 were useful prognostic marker for gastric cancer patients. Therefore, the detection of tenascin, MVD and Ki-67 may be valuable to evaluate biological behavior for patients with gastric cancer during clinical treatment.