| 实验小鼠在癌症研究中的应用及其进展 |
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| 引用本文： | 王硕,苏杭,袁经权,缪剑华.实验小鼠在癌症研究中的应用及其进展[J].中国实验动物学杂志,2011(9):63-67. |
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| 作者姓名： | 王硕 苏杭 袁经权 缪剑华 |
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| 作者单位： | [1]广西药用植物研究所姚新生院士重点实验室,南宁530023 [2]广西医科大学,南宁530021 [3]广西中医学院,南宁530001 |
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| 基金项目： | 桂科攻（0992003-3） |
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| 摘 要： | 小鼠是生物医学研究中使用数量最多的哺乳类实验动物。人类利用小鼠模型进行癌症研究已有100多年的历史,小鼠大量的遗传变异可作为研究人类癌症的借鉴。特别是近年来,培育成功的转基因、基因敲除等遗传工程小鼠模型,使我们对人类癌症发生有了深刻的认识,为评估癌症的诊断方法,革新预防和治疗方案提供了一个很有价值的平台。本文着重介绍了癌症研究中常用的小鼠模型、GEM模型及取得的最新进展等,分析了小鼠肿瘤模型的局限性,并对其发展趋势进行展望。
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| 关 键 词： | 小鼠 模型 癌症 |
Application and Recent Advances of Laboratory Mouse in Cancer Research |
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| WANG Shuo,SU Hang,YUAN Jing-quan,MIAO Jian-hua.Application and Recent Advances of Laboratory Mouse in Cancer Research[J].Chinese Journal of Laboratory Animal Science,2011(9):63-67. |
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| Authors: | WANG Shuo SU Hang YUAN Jing-quan MIAO Jian-hua |
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| Institution: | 1.The key Laboratory of Academician Yao Xin-sheng,Institute of Guangxi Medicinal Plant,Nanning 530023,China; 2.Guangxi Medical University,Nanning 530021,China; 3.Guangxi Traditional Chinese medical University,Nanning 530001,China) |
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| Abstract: | Mouse is the most popular laboratory animal in medical research.As an animal model,mouse has been used for human cancer research for over one century,a large number of genetic variations in mice can be used as reference for the study of human cancer.Over the past 20 years,genetically engineered mouse（GEM）,including transgenic mouse,knock-out mouse,have been cultured,thus,paved a way to deepen our understanding of cancer diagnosis,innovative therapeutic,and prevention.In this review paper,we mainly introduce spontaneous and inducible cancer mouse models and GEM models.In addition,some recent strategies and accomplishments for producing complicated cancer models in the mouse as well as the limitation of mouse model are discussed. |
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| Keywords: | Mouse Model Cancer |
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