术中局部化疗对大肠癌患者预后影响的临床观察

目的：观察术中局部化疗对大肠癌患者的预后影响，探讨提高大肠癌患者临床疗效的辅助治疗方法。方法：选择DuckB期和DuckC期患者76例，根据自愿的原则均分为常规手术组和术中化疗组，常规手术组采取常规手术治疗，术中化疗组在常规手术过程中给予局部化疗治疗，比较两组患者术后第7d血常规、肝肾功能及两组患者术后并发症，并随访两组患者术后12个月和24个月局部复发情况。结果：两组患者在术后血常规、肝肾功能及术后并发症方面比较，差异无统计学意义（P〉0．05）；术后12个月和24个月局部复发病例比较，差异具有统计学意义①〈0．05），术中化疗组显著少于常规手术组。结论：在DuckB期和DuckC期大肠癌患者外科手术治疗过程中．应积极采取术中化疗的治疗措施。

The Clinical Prognosis Observation of Intraoperative Local Chemotherapy on the Patients with Colorectal Cancer

Objective： To observe the clinical prognosis of intraoperative local chemotherapy on the patients with colorectal cancer and research the adjuvant therapy to improve the clinical effect of the patients with colorectal cancer. Methods： Choose the patients in the Duck B period and Duck C period,according to the principle of voluntary, they were divided into the conventional surgery group and intraoperative chemotherapy group, then compare the routine blood test, liver and kidney function and postoperative complications,and compare the local recurrence patients after 12 months and 24 months. Results： There was no significant （P 〉 0.05） in the routine blood test, liver and kidney function and postoperative complications; There has a significant statistical difference （P〈0.05） in the local recurrence patients after 12 months and 24 months,the intraoperative chemotherapy group was significantly less than the conventional surgery group. Conclusion： We should take the measures of intraoperative chemotherapy during treating the colorectal cancer patients with the Duck B period and Duck C period.