三种抗癫痫药对癫痫患者脑电图的背景影响比较研究

目的：研究对比三种抗癫痫药（苯妥因钠、丙戊酸钠、卡马西平）对癫痫患者脑电图的背景影响。方法：选取我院于2009年3月至2011年2月收治的60例癫痫患者，随机分为苯妥因钠（PHT）、卡马西平（CBZ）和丙戊酸钠（SVP）组各20例，动态观察各组患者于治疗期间痫样波放电的频度和EEG背景的变化。结果：EEG痫样波放电的抑制率以SVP最为明显，而CBZ在EEG背景活动影响方面均比其他两组显著。结论：三种药物对癫痫波放电的抑制顺序是SVP〉PHT〉CBZ，SVP组明显优于其他两组。

Comparative Study on the Effects of Three Kinds of Antiepileptic Drugs on EEG Background of Patients with Epilepsy

Objective： To study an compare the effect of three kinds of antiepileptic drugs （phenytoin, sodium valproate, carbamazepine） on patients with Epilepsy EEG background. Methods： In our hospital from March 2009 to February 2011, 60 cases of epilepsy patients were randomized to phenytoin （PHT）, carbamazepine （CBZ） and valproate （SVP） group with 20 cases in each group. Dynamic observation was performed in all groups of patients to detect the changes of epileptiform discharges frequency and EEG background during treatment period. Results： EEG epileptiform discharges inhibition rate of SVP was most obvious, and EEG background activity effects were stronger in CBZ than other two groups. Conclusions： The order of the three kinds of drugs in suppressing epileptic wave discharge is SVP 〉 PHT 〉 CBZ, and SVP group was significantly better than the other two groups.