心理干预对非小细胞肺癌患者免疫功能及心理状态的临床研究

目的：研究心理干预对非小细胞肺癌患者免疫功能及心理状态的影响。方法：70例NSCLC患者随机分为治疗组（Tl=36）和阳性对照组（n=34），另设正常对照组（n=30），治疗组进行心理干预，阳性对照组和正常对照组不给予干预，30天后，计算患者的EORTCQLQ—C30积分并测定T细胞亚群CD3＋、CD4＋、CD8＋、CD4＋／CD8＋指标。结果：治疗组患者干预后的生存质量（一般情况、躯体功能、社会功能等）及CD3＋、CD4＋、CD8＋含量较干预前均有差异（P〈0．01或P〈0．05），治疗组患者干预后的生存质量及CD3＋、CD4＋、CD8＋含量较阳性对照组干预后均有差异（P〈0．01或P〈0．05）。结论：心理干预对非小细胞肺癌患者的心理状态有积极作用，同时能提高患者的免疫力。

Effects of Psychological Intervention on Immune Function and Mental State in Patients with Non- small Cell Lung Cancer

Objective： To investigate the effect of psychological intervention on the immune function and mental state in patients with non-small cell lung cancer. Methods： A total of 70 patients with NSCLC were randomized into 2 groups：experimental group, 36 cases with psychological intervention, 34 cases in the positive controlled group without intervention. Blank controlled group consists of 30 healthy individuals. After 30days, the score ofEORTC QLQ- C30 were calculated and content ofT cell subsets CD3＋, CD4＋, CD8＋, CD4＋/CD8＋ were tested. Results： Before and after intervention, the score of EORTC QLQ-C30 and content of T cell subsets CD3＋, CD4＋, CD8＋ were significantly different in the experimental group （P〈0.01 or P〈0.05）. After intervention, the score of EORTC QLQ-C30 and content of T cell subsets CD3＋, CD4＋, CD8＋ were significantly different in the experimental group compared with those of positive controlled group （P〈0.01 or P〈0.05 ）. Conclusions： Psychological intervention on patients with NSCLC not only has an active effect on mental state, but also can improve the patient＇s immune function.