血清降钙素原检测对早期诊断新生儿败血症的临床价值

目的：探讨血清降钙素原（PCT）作为早期诊断新生儿败血症指标的临床价值。方法：应用免疫色谱法对101例新生儿进行PCT水平测定，并与C反应蛋白（CRP）作比较。将患儿按出院诊断分为败血症组、一般感染组、非感染组进行分析。结果：败血症组患儿血清PCT和CRP明显高于一般感染组和非感染组，差异有统计学意义（P〈0．05）；一般感染组与非感染组血清PCT、CRP比较差异有统计学意义（P〈0．05）。以0．5ng／mL为临界值，PCT诊断新生儿败血症的敏感度为92．11％，特异度为78．79％；以8．0mg／L为临界值，诊断败血症的敏感度为65．79％，特异度为69．70％。与CRP相比，PCT诊断败血症的敏感性、特异性更高。经有效抗生素治疗后，血清PCT下降幅度明显大于血清CRP下降幅度。结论：新生儿血清中PCT水平的检测对败血症的早期诊断及病情程度判断、治疗效果的评价具有重要价值。

The Value of Serum Procalcitonin in the Early Diagnosis of Neonatal Septicemia

Objective： To investigate Procalcitonin （FCT） for early diagnosis of neonatal septicemia. Methods： The serum PCT levels were measured with immune chromatography （PCT-Q） assay and compared with the serum C-reactive protein （CRP） in 101 neonates. To assignment the neonates for three groups with discharage diagnosis, 101 neonates were divided into neonatal septicemia group, common infection group and non-infection group according to discharge diagnosis. Results： Serum concentrations of PCT and CRP in neonatal septicemia group were significantly higher than those common group and non-infection group （all P 〈 0.05 ）. Serum concentrations of PCT and CRP in neonates with common infection cares were significantly higher than those non-infection cares （P〈 0.05 ）. Set 0.5ng/ml for a critical value, PCT was positive in 92.11% neonatal septicemia cases, the specificity rate was 78.79%. Set 8.0ng/ml for a critical value ,PCT was positive in 65.79% neonatal septicemia cases, the specificity rate was 69.70%. The sensitivity and specificity rate of PCT were much higher than that of CRP. The level of the serum PCT decreased rapidly during effective antibiotic therapy. Conclusions： The measurement of PCT will be very important to the early and differential diagnosis and judgment of therapeutic efficacy of neonatal infection.