| 心脏特异抗凋亡蛋白ARC研究进展 |
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| 引用本文： | 廉虹,张连峰.心脏特异抗凋亡蛋白ARC研究进展[J].中国实验动物学杂志,2011(3):59-61. |
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| 作者姓名： | 廉虹 张连峰 |
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| 作者单位： | [1]中国医学科学院实验动物研究所,卫生部人类疾病比较医学重点实验室,北京100021 [2]中国医学科学院实验动物研究所,国家中医药管理局人类疾病动物模型三级实验室,中国医学科学院和北京协和医学院,北京100021 |
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| 基金项目： | 卫生部行业基金 实验动物和人类疾病动物模型资源扩展（200802036）; 十一五新药专项支持（2009ZX09501-026） |
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| 摘 要： | 含胱冬肽酶富集功能域的凋亡抑制因子（apoptosis repressor with CARD,ARC）蛋白是20世纪末发现的在心肌、骨骼肌和大脑等终末分化组织中大量表达的抗凋亡蛋白。ARC的主要功能是抗凋亡作用。由于其在心脏中表达的特异性和抗凋亡的多层次性,使ARC在心脏中的作用成为近年来研究的热点。本文主要对其抗凋亡途径以及近年来在心肌病中的研究进展两方面进行综述。
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| 关 键 词： | 含胱冬肽酶富集功能域的凋亡抑制因子 凋亡 心肌病 |
The Advances in Heart Specific Anti-apoptosis Protein ARC |
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| LIAN Hong,ZHANG Lian-feng.The Advances in Heart Specific Anti-apoptosis Protein ARC[J].Chinese Journal of Laboratory Animal Science,2011(3):59-61. |
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| Authors: | LIAN Hong ZHANG Lian-feng |
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| Institution: | 1.Key Laboratory of Human Disease Comparative Medicine,Ministry of Heath,Institute of Laboratory Animal Science,Chinese Academy of Medical Sciences ＆ Peking Union Medical College,Beijing 100021,China;2.Human Disease Animal Models Level-3 Laboratory of State Administration of Traditional Chinese Medicine,Institute of Laboratory Animal Science,Chinese Academy of Medical Sciences ＆ Peking Union Medical College,Beijing 100021,China) |
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| Abstract: | ARC（apoptosis repressor with CARD） protein expressed at high levels in the terminally differentiated tissues,such as,heart,skeletal muscle and brain,which was identified at the end of last century.ARC inhibits apoptosis at different levels.Since the specific expression of ARC in heart and antagonize apoptosis in many pathways,it became a hot-spot in recent years.With the function of anti-apoptosis,ARC has become a protecting factor for heart muscle.This review mainly focuses on the anti-apoptosis pathways and recent-year advances on ARC in cardiomyopathy. |
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| Keywords: | Apoptosis repressor with CARD（ARC） Apoptosis Cardiomyopathy |
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