姜黄素对高原缺氧大鼠认知功能障碍的预防作用

目的：探讨姜黄素（curcumin）对高原缺氧大鼠认知功能障碍的预防作用。方法：将30只成年雄性SD大鼠随机分为健康对照组、模型组（Model组）、姜黄素【按体重60mg／（kg·d）】治疗组（curcumin组）。采用Morris水迷宫实验方法检测缺氧后大鼠学习记忆功能变化，同时检测脑片水平的LTP变化。结果：（1）模型组大鼠寻找平台的潜伏期明显长于对照组，具有统计学意义（P〈0．05），姜黄素组寻找平台的潜伏期相对于模型组显著缩短（P〈0．05）。撤离平台后，模型组大鼠在平台所在象限的停留时间明显短于对照组（P〈0．05），姜黄素干预后大鼠在平台所在象限的停留时间较模型组显著延长（P〈0．05）。（2）给予HFS刺激后各组兴奋性突出后电位（fEPSP）斜率较前明显增加，均可持续1h以上，与模型组比较缺氧组HFS刺激后fEPSP斜率明显减小（P〈0．05），姜黄素可减轻缺氧所致的fEPSP斜率减小（P〈0．05）。结论：姜黄素可改善慢性缺氧大鼠认知功能障碍，但其具体机制尚有待于进一步研究。

Curcumin Attenuates Hypobaric Hypoxia-Induced Cognitive Deficits

Objective： To investigate the effects of curcumin on cognitive deficits induced by hypobaric hypoxia. Methods： 30 male Sprague-Dawley rats （200± 20 g） were randomly divided into three groups with 10 rats in each group： Control group, Model group and Curcumin group. Severe cognitive deficits were detected by the water maze task. Hippocampal LTP was measured by electrophysiol- ogy method. Results： Hypobaric hypoxia can cause severe cognitive deficits, and curcurnin could attenuate hypobaric hypoxia-induced cognitive deficits. LTP inhibition in hippocampus caused by hypobaric hypoxia were markedly improved by administration of curcumin for 4 weeks. Conclusions： Curcumin exhibits therapeutic potential for hypobaric bypoxia-induced cognitive deficits.