| 营养与病毒感染性疾病动物模型 |
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| 引用本文： | 窦建琳,张宏福,唐湘方.营养与病毒感染性疾病动物模型[J].中国实验动物学杂志,2011(9):71-74. |
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| 作者姓名： | 窦建琳 张宏福 唐湘方 |
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| 作者单位： | [1]兰州大学基础医学院病原生物学研究所,兰州730000 [2]中国农业科学院北京畜牧兽医研究所,动物营养学国家重点实验室,北京100093 |
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| 基金项目： | 动物营养学国家重点实验室开放课题资助（2004DA125184F1107）; 兰州大学中央高校基本科研业务费专项资金资助（lzujbky-2010-122）; 转基因新品种重培育重大专项经费资助（2009ZX08012-015B） |
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| 摘 要： | 当前新现病毒性疾病的研究最大的＂瓶颈＂在于没有胜任动物模型。建立在非人灵长类动物基础上的模型,虽然可以部分复制人类疾病特征,但其经济性欠佳且与动物权益的保护有所冲突;而啮齿类动物对新现病毒的易感性往往较低,也不能很好地复制人类疾病。本文对营养、免疫及疾病易感性关系研究的进展进行文献回顾,以发现解决当前难题的线索。
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| 关 键 词： | 营养 疾病易感性 病毒感染动物模型 粘膜免疫 |
Nutrition and Animal Models of Virus Infection |
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| DOU Jian-lin,Zhang Hong-fu,Tang Xiang-fang.Nutrition and Animal Models of Virus Infection[J].Chinese Journal of Laboratory Animal Science,2011(9):71-74. |
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| Authors: | DOU Jian-lin Zhang Hong-fu Tang Xiang-fang |
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| Institution: | 1.Institute of Pathogenic Biology,School of Basic Medical Sciences,Lanzhou University,Lanzhou 730000,China; 2.State Key Laboratory of Animal Nutrition,Institute of Animal Sciences, Chinese Academy of Agricultural Sciences,Beijing 100093,China) |
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| Abstract: | The studies on emerging viral diseases are restrained by a ＂bottle neck＂： no competent animal model available.Models based on nonhuman primates have similar clinical manifestations to human diseases;however,it is uneconomic to construct such models.Furthermore,there is a controversy about protection of animal rights.Models based on rodents are often incompetent due to their low susceptibility for those viruses.This brief review focuses on the current studies on relations among nutrition,immunity and susceptibility to give insights in overcoming conundrums. |
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| Keywords: | Nutrition Susceptibility Animal models of virus infection Mucosal immunity |
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