154例药品不良反应监测报告分析

目的：分析我院2009和2010年收集的154例药品不良反应（ADR）报告，以期了解不良反应发生的特点和规律，减少或避免不良反应的重复发生，为临床科室合理用药提供参考。方法：采用回顾性分类统计方法，对我院2009和2010两年上报的154例报告就ADR分布与年龄、给药途径、药物分类、累及系统及器官等方面的关系进行统计分析。结果：154例不良反应报告中以抗微生物药物和中药注射剂为主，分别占44．81％和20．78％。ADR临床表现以变态反应为主，其中儿童和老年患者居多（33．12％和48．05％），以静脉滴注方式为主（91．55％），临床表现主要以皮肤及其附件损伤最常见（75．97％）。结论：应加强ADR监测上报工作，并及时向临床科室反馈，提高临床安全用药意识，确保临床用药安全。

Analysis of 154 Cases of Adverse Drug Reaction Reports

Objective： Analyze of 154 cases reported and collected in our hospital in 2009 and 2010 to understand the characteristics and law of adverse drug reaction （ADR） occurrence for promoting rational drug use in clinic. Methods： 154 cases reported and collected in our hospital in 2009 and 2010 were retrospectively analyzed. The statistical analysis was performed on age, route of administration, drug type, adverse reactions and clinical manifestations. Results： Most of ADR were induced by antibiotics and TCM injections, account- ing for 44.81% and 20.78% respectively. 91.55% cases were caused by intravenous drip. The injuries of skin and accessories were most common, accounting for 75.79%. Conclusion： ADR monitoring should be attached importance in clinic, especially the observation on the medication course in the children and elderly. Antimicrobial agents and TCM injections should be rationally used to prevent or reduce the occurrence of ADR.