阿米替林对脊髓电刺激治疗幻肢痛疗效的影响

目的：本研究旨在探讨阿米替林干预对脊髓电刺激（SCS）治疗幻肢痛疗效的影响。方法：研究对象为2007年1月至2009年6月在我科行SCS置入术且符合入组标准并自愿参加研究的幻肢痛患者，共获7例。术后SCS均开启，阿米替林治疗在术后1个月时开始。疼痛、情绪、生活质量评估采用视觉模拟评分法（visual analogue scales，VAS法），现时疼痛强度评分法（presentpain intensity。PPI），综合性医院焦虑抑郁量表（The Hospital Anxiety and Depression Scale，HAD），疼痛失能指数（Pain disability index，PDI）。结果：（1）开启SCS后患者的疼痛、抑郁焦虑情绪及生活质量均得到显著改善。（2）所有患者在使用阿米替林治疗以后疼痛、情绪及生活质量也显著改善。结论：阿米替林能显著提高SCS对幻肢痛的疗效。

Influence of Amitriptyline to the Effectiveness of the Spinal Cord Stimulation to the Phantom Limb Pain

Objective： We aimed to study how the amitriptyline intervention would have impact the curative effects of the phantom limb pain （PLP） patients who had been treated with the spinal cord stimulation （SCS）. Methods： All the PLP patients who accepted the SCS implantation at our therapy centre during January 2007 to June 2009 and who fit in the selected standard and were the volunteers to this research were selected as subjects and we obtained 7 patients finally. All the patients＇ SCS were opened post-operation immediately and all the patients were taken amitriptyline one month post-operation. We used visual analogue scales （VAS）, present pain intensity （PPI）, the hospital anxiety and depression scale（HAD） and pain disability index（PDI） to assess the severity of pain, mood and the quality of life of the patients. Results： The pain, depression and anxiety mood and quality of life of these patients were improved dramatically after opened SCS post-operation. We obtained the same consequence after taken amitriptyline post-operation. Conclusion： Amitriptyline can promote the effectiveness of SCS of the PLP patients.