Microbial l-methioninase: production, molecular characterization, and therapeutic applications |
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Authors: | Ashraf S El-Sayed |
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Institution: | (1) Present address: Microbiology Department, Faculty of Science, Zagazig University, Zagazig, Egypt |
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Abstract: | l-Methioninase is ubiquitous in all organisms except in mammals. It mainly catalyzes the, α, γ-elimination of l-methionine to α-ketobutyrate, methanethiol, and ammonia. Unlike normal cells, methionine dependency was reported as a biochemical
phenomenon among various types of cancer cells. Thus, l-methioninase is the universal protocol for triggering the majority of tumor cells. This review is an attempt to briefly describe
the occurrence of the biochemical and molecular properties of l-methioninase by a comparative manner to the eukaryotic and prokaryotic source for the maximum exploitation in the therapeutic
field. The combination of l-methioninase treatment, gene therapy, and chemotherapeutic drugs clearly explores the various therapeutic aspects of this
enzyme. Finally, the perspectives for increasing the therapeutic efficacy of this enzyme were described. |
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