Antimutagenic activity of mitochondria-targeted plastoquinone derivative |
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Authors: | V A Chistyakov M A Sazykina A A Alexandrova N I Belichenko E V Mashkina L V Gutnikova P V Zolotukhin T P Shkurat |
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Institution: | (1) School of Industrial Technology, Universiti Sains Malaysia, 11800 Penang, Malaysia |
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Abstract: | The ability of cationic plastoquinone derivative 10-(6′-plastoquinonyl) decyltriphenylphosphonium (SkQ1) to modify processes
of spontaneous and induced mutagenesis was studied. It is shown that daily introduction of this compound into male Wistar
rats in doses of 25 and 250 nmol/kg during two weeks decreases spontaneous level of chromosome aberrations in anaphase in
the eye cornea from 0.39 ± 0.09 to 0.13 ± 0.08 and 0.14 ± 0.05, respectively. The level of 8-hydroxy-2′-deoxyguanosine in
blood serum of the investigated animals decreases from 32.12 ± 1.55 to 25.90 ± 2.26 and 25.76 ± 1.50 ng/ml, respectively.
These facts indicate that the decrease in spontaneous clastogenesis is caused by decreased level of DNA damage by endogenous
reactive oxygen species. A higher dose of SkQ1 also decreases to control level chromosome aberrations caused by oxygen under
pressure of 0.5 MPa for 60 min. It is also shown in experiments with bacterial biosensors that SkQ1 is able to efficiently
protect cells against genotoxic effect of UV radiation at 300–400 nm. |
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