Novel radiosynthesis of PET HSV-tk gene reporter probes [18F]FHPG and [18F]FHBG employing dual Sep-Pak SPE techniques |
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| Authors: | Wang Ji-Quan Zheng Qi-Huang Fei Xiangshu Mock Bruce H Hutchins Gary D |
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| Institution: | Department of Radiology, Indiana University School of Medicine, 1345 West 16th Street, L-3 Room 202, Indianapolis, IN 46202-2111, USA. |
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| Abstract: | Positron emission tomography (PET) herpes simplex virus thymidine kinase (HSV-tk) gene reporter probes 9-(3-(18)F]fluoro-1-hydroxy-2-propoxy)methyl]guanine ((18)F]FHPG) and 9-(4-(18)F]fluoro-3-hydroxymethylbutyl)guanine ((18)F]FHBG) were prepared by nucleophilic substitution of the appropriate tosylated precursors with (18)F]KF/Kryptofix 2.2.2 followed by a quick deprotection reaction and purification with a simplified dual Silica Sep-Pak solid-phase extraction (SPE) method in 15-30% radiochemical yield. |
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