Non-transferrin-bound iron in plasma following administration of oral iron drugs |
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Authors: | Bernd Dresow Doerte Petersen Roland Fischer Peter Nielsen |
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Institution: | 1.Inst. für Biochemie und Molekularbiologie II: Molekulare Zellbiologie,Zentrum für Experimentelle Medizin Universit?tsklinikum Hamburg-Eppendorf,Hamburg,Germany |
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Abstract: | Non-transferrin-bound iron (NTBI) was detected in serum samples from volunteers with normal iron stores or from patients with
iron deficiency anaemia after oral application of pharmaceutical iron preparations. Following a 100 mg ferrous iron dosage,
NTBI values up to 9 μM were found within the time period of 1–4 h after administration whereas transferrin saturation was
clearly below 100%. Smaller iron dosages (10 and 30 mg) gave lower but still measurable NTBI values. The physiological relevance
of this finding for patients under iron medication has to be elucidated. |
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Keywords: | Non-transferrin-bound iron— NTBI Oral iron drugs Transferrin saturation Iron medication Risk factor |
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