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Separation of retinoblastoma and esterase D loci in a patient with sporadic retinoblastoma and del(13)(q14.1q22.3)
Authors:Robert S Sparkes  Maryellen C Sparkes  Robert E Kalina  Roberta A Pagon  Darrell J Salk  Christine M Disteche
Institution:(1) Division of Medical Genetics, Department of Medicine, UCLA School of Medicine, Los Angeles;(2) Department of Pediatrics, UCLA School of Medicine, Los Angeles;(3) Department of Psychiatry, UCLA School of Medicine, Los Angeles;(4) Center for the Health Sciences, Los Angeles;(5) Department of Ophthalmology, University of Washington School of Medicine, Seattle, USA;(6) Department of Pediatrics, University of Washington School of Medicine, Seattle, USA;(7) Department of Pathology, University of Washington School of Medicine, Seattle, USA;(8) Childrens Orthopedic Hospital and Medical Center, Seattle, USA
Abstract:Summary A chromosome 13 deletion in a patient with sporadic retinoblastoma appears to have separated the loci for retinoblastoma and esterase D. This study indicates that: (1) the retinoblastoma locus is distinct from the esterase D locus; and (2) the linear order of these genes is centromere-esterase D-retinoblastoma.
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