Synthesis and cytotoxic activities of analogues of thuriferic acid. |
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Authors: | Blanca Madrigal Pilar Puebla Angel Ramos Rafael Peláez Dolores Grávalos Esther Caballero Manuel Medarde |
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Institution: | Laboratorio de Química Orgánica y Farmacéutica, Facultad de Farmacia. Campus Miguel de Unamuno, 37007-Salamanca, Spain. |
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Abstract: | Several analogues of thuriferic acid and derivatives, with the 3,4-methylenedioxyphenyl ring replaced by naphthalene, furan, thiophene and carbazole ring systems, have been prepared. The synthetic strategy is based on a conjugate addition-alkylation methodology followed by cationic cyclization in order to obtain the isopodophyllone analogues, which are transformed in the thuriferic acids. Their cytotoxic activities against several tumour cells lines are also described. |
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