Oxidative Stress and S100B Protein in Cirrhotic Children |
| |
Authors: | Luciana Ribeiro Ana Cristina Andreazza Mirian Salvador Themis Reverbel da Silveira Sandra Vieira Daniel Bocchese Nora Cleonice Bosa Francesca Di Napoli Débora Vigevani Schaf Diogo Onofre Souza Luis Valmor Cruz Portela Flávio Kapczinski |
| |
Institution: | Laboratório de Psiquiatria Experimental, Hospital de Clínicas de Porto Alegre e Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil. lribeiro@med.miami.edu |
| |
Abstract: | Cirrhosis represents the terminal stage of a number of chronic liver diseases. Consequences include accumulation of toxic
metabolic wastes, reduced synthesis of key proteins, increased portal venous pressure, and portosystemic shunting. We conducted
a case-control study to assess the serum levels of S100B protein and parameters of oxidative stress, superoxide dismutase
(SOD), catalase (CAT) and oxidative stress measured by the thiobarbituric acid method (TBARS), in a group of 14 pediatric
patients with cirrhosis. No differences were found between groups in S100B protein levels. SOD activity and TBARS levels were
higher; and CAT activity was lower in the cirrhotic group. A negative correlation between S100B and TBARS in the case group
was found (r = −0.815, p = 0.001). Conclusions: This study didn’t indicate a possible role of S100B serum levels as marker of brain damage in cirrhotic children but suggest
a possible relation between astrocyte function and oxidative damage in cirrhotic children. |
| |
Keywords: | Cirrhosis Liver disease Children Oxidative stress S100B protein |
本文献已被 PubMed SpringerLink 等数据库收录! |
|