Biological evidence for a precursor protein of serum albumin. |
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Authors: | J Urban G Schreiber |
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Affiliation: | The Russell Grimwade School of Biochemistry, Melbourne University, Parkville, Victoria, 3052, Australia |
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Abstract: | Radioactive leucine was injected into the portal vein of rats followed after 15 seconds by a 180 fold excess of nonradioactive leucine. An albumin-like protein in the liver became highly labelled within 15 minutes after injection. After 150 minutes, the radioactivity in the albumin-like protein had decreased to one tenth. In the serum, radioactively labelled albumin started to appear after 15 minutes and increased there-after up to 150 minutes after injection. Radioactivity in albumin within the liver remained constant at a low level. These results suggest that the albumin-like protein is a biological precursor protein of serum albumin, i.e. a proalbumin. |
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