Swiveling and decatenation of replicating simian virus 40 genomes in vivo. |
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| Authors: | R M Snapka M A Powelson and J M Strayer |
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| Institution: | Department of Radiology, Ohio State University, Columbus 43210. |
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| Abstract: | We have found that type II topoisomerase inhibitors have two effects on replicating simian virus 40 genomes in vivo: production of catenated dimers and slowed replication of the last 5% of the genome. This suggests that type II topoisomerase simultaneously decatenates and facilitates replication fork movement at this stage of DNA replication. On the basis of this observation, a detailed model is proposed for the roles of topoisomerases I and II in simian virus 40 DNA replication. |
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