Antifertility effect of tamoxifen as tested in the female bonnet monkey (Macaca radiata) |
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Authors: | N Ravindranath N R Moudgal |
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Institution: | (1) Department of Biochemistry, Center for Advanced Research in Reproductive Biology, Indian Institute of Science, 560 012 Bangalore, India |
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Abstract: | The administration of a potent antiestrogen, tamoxifen at a dose of 3 mg/kg body weight/day orally post-coitally to cycling
mated bonnet monkeys(Macaca radiata) from days 18–30 of cycle resulted in inhibition of establishment of pregnancy in 9 out of 10 monkeys. Tamoxifen effect was
not due to interference with luteal function. The effect was specific to tamoxifen as exogenously administered progesterone
could not reverse it. In addition to suggesting a role for estrogen in maintenance of early pregnancy in the primate the present
study could be a prelude to the development of an effective post-ovulatory approach for regulation of fertility in the human
female |
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Keywords: | Antiestrogen implantation pregnancy primate post-coital contraception |
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