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Expression of EpCAM in uveal melanoma |
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| Authors: | Danilo N Odashiro Alexandre N Odashiro Patrícia R Pereira Katyanne Godeiro Emilia Antecka Sebastian Di Cesare Miguel N Burnier Jr |
| Affiliation: | 1. Henry C. Witelson Ocular Pathology Laboratory, McGill University, Montreal, QC, Canada 2. Department of Ophthalmology, Federal University of S?o Paulo (UNIFESP), S?o Paulo, Brazil 3. LAC-Pathology and Cytopathology Laboratory, Campo Grande, MS, Brazil 4. Universidade para o Desenvolvimento do Estado e Regi?o do Pantanal (UNIDERP), Campo Grande, MS, Brazil |
| Abstract: | BackgroundUveal melanoma (UM) is the most common primary intraocular malignant tumor in adults, and nearly 40% of UM will develop metastasis that will ultimately lead to death. The Epithelial Cell Adhesion Molecule (EpCAM) is a type I transmembrane glycoprotein expressed by carcinomas of head and neck, ovary, colon, breast, kidney and lung. Recently, antibodies against EpCAM such as Edrecolomab and Catumaxomab were developed, and clinical trials with these antibodies have been used in several types of neoplasia. We studied the expression of EpCAM in UM. |
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